Radiomics model based on preoperative gadoxetic acid-enhanced MRI for predicting liver failure

BACKGROUND Postoperative liver failure is the most severe complication in cirrhotic patients with hepatocellular carcinoma(HCC) after major hepatectomy. Current available clinical indexes predicting postoperative residual liver function are not sufficiently accurate.AIM To determine a radiomics model based on preoperative gadoxetic acid-enhanced magnetic resonance imaging for predicting liver failure in cirrhotic patients with HCC after major hepatectomy.METHODS For this retrospective study, a radiomics-based model was developed based on preoperative hepatobiliary phase gadoxetic acid-enhanced magnetic resonance images in 101 patients with HCC between June 2012 and June 2018. Sixty-one radiomic features were extracted from hepatobiliary phase images and selected by the least absolute shrinkage and selection operator method to construct a radiomics signature. A clinical prediction model, and radiomics-based model incorporating significant clinical indexes and radiomics signature were built using multivariable logistic regression analysis. The integrated radiomics-based model was presented as a radiomics nomogram. The performances of clinical prediction model, radiomics signature, and radiomics-based model for predicting post-operative liver failure were determined using receiver operating characteristics curve, calibration curve, and decision curve analyses.RESULTS Five radiomics features from hepatobiliary phase images were selected to construct the radiomics signature. The clinical prediction model, radiomics signature, and radiomics-based model incorporating indocyanine green clearance rate at 15 min and radiomics signature showed favorable performance for predicting postoperative liver failure(area under the curve: 0.809-0.894). The radiomics-based model achieved the highest performance for predicting liver failure(area under the curve: 0.894; 95%CI: 0.823-0.964). The integrated discrimination improvement analysis showed a significant improvement in the accuracy of liver failure prediction when radiomics signature was added to the clinical prediction model(integrated discrimination improvement = 0.117, P =0.002). The calibration curve and an insignificant Hosmer-Lemeshow test statistic(P = 0.841) demonstrated good calibration of the radiomics-based model. The decision curve analysis showed that patients would benefit more from a radiomics-based prediction model than from a clinical prediction model and radiomics signature alone.CONCLUSION A radiomics-based model of preoperative gadoxetic acid–enhanced MRI can be used to predict liver failure in cirrhotic patients with HCC after major hepatectomy.     

中风后癫痫59例分析

对641例中风患者追踪观察1～3年,结果59例出现癫痫发作,中风后癫痫发生率为9.20％;脑出血与脑梗塞癫痫发生率间比较无已著差异(P>0.05);皮层损害者癫痫发生率显著高于皮层下损害者(P<0.01);脑出血继发癫痫发作多属早期发作(8/11),而脑梗塞多属迟发性癫痫发作(40/48)(P<0.01);早期癫痫发作需长期服抗癫痫药控制者显著低于迟发性癫痫发作(P<0.01)。提示:病损波及皮层是重要的致痫因素;早期发作与迟发性癫痫发作的发病机理不同,故表现出治疗与转归不同;迟发性癫痫尤其病灶波及皮层者长期规则服抗癫痫药是必要的。     

对氯烯雌酚醚防治雌性大鼠去势后骨丢失的评价

目的：了解氯烯雌酚醚对去势雌性大鼠骨代谢的影响。方法：鼠龄７０天的Ｗｉｓｔａｒ雌鼠４８只，分别予假性手术与注射用油（ＳＶ组）、去势与注射用油（ＯＶ组）、假性手术与氯烯雌酚醚（ＳＥ组）及去势与氯烯雌酚醚（ＯＥ组）等处理，双侧卵巢去势或假性手术后７天，于每晚腹腔注射氯烯雌酚醚或注射用油４ｍｌ／ｋｇ，共４５天。处死大鼠时，测定子宫湿重，同时收集第１２胸椎和左胫骨制成脱钙骨切片，行骨组织形态计量学测定。结果：４组间子宫重量差异均有显著性。骨组织形态计量学显示，（１）ＯＶ与ＳＶ、ＳＥ及ＯＥ组间差异有显著性；（２）ＯＥ、ＳＥ和ＳＶ组间差异无显著性。结论：氯烯雌酚醚能抑制Ｗｉｓｔａｒ雌鼠去势后的骨丢失，减缓去势后的子宫萎缩，对骨骼有雌激素样的保护作用。     

紫外分光光度法测定对乙酰氨基酚泡腾片含量

本文用紫外分光光度法在２５７±１ｎｍ波长处测定对乙酰氨基酚泡腾片的含量，其浓度与吸收度的线性关系良好，相关系数ｒ＝０．９９９９８。平均回收率为９９．９４％，变异系数为０．２０％。本法简便、快速、结果准确。     

口服二巯基丁二酸治疗狗路易氏剂中毒

为证实口服二巯基丁二酸（ＤＭＳＡ）治疗路易氏剂中毒的效价，以狗为实验动物，进行实验治疗研究，狗口服ＤＭＳＡ（４０～１２０ｍｇ／ｋｇ）后，２周内未见到有关的生理，生化指标明显变化，该药毒性较小。ＤＭＳＡ可在肠道内较好地被吸收，与静脉注射途径比较，口服组血药浓度上升慢，下降亦慢，可在体内维持较长时间，ＤＭＳＡ在体内促排砷的作用与静脉注射同剂量ＤＭＳＡ（钠盐）相当。狗口服ＤＭＳＡ４０ｍｇ／ｋｇ可对抗路易     

边远驻军官兵身心健康状况及相关因素的调查

目的：调查边远驻军官兵的身心健康状况及其影响因素。方法：以边远驻军官兵为被采用症状自评量素（SCL－90），孤独量表（非大学生版）及自编的一般情况问卷进行测评。结果：250人中有72人（29．2％）存在不同程度的身心健康问题，其中人际敏感，躯体化和强迫症状等是边远驻军官兵主要问题，与部队常模及军校大学生比较，边远驻军官兵的身心健康水平相对较差；其身心健康问题与孤独感，对环境的不适应，睡眠问题及自慰行为存在着显著的线性关系。结论：总体上边远驻军兵的身心健康水平相对较差，存在身心症状的人数较多，其中孤独感，对环境的不适应，睡眠问题及自慰行为等是主要的影响因素。     

Predictors of post coronary artery bypass grafting atrial fibrillation

Objective: To investigate the incidence and relative risk factors of post coronary artery bypass grafting(post-CABG) atrial fibrillation (AF). Methods: 312 patients with CABG were reviewed and divided into an AF group and a non-AF group. Statistical analysis was used to compare the data between the two groups and screen for risk factors of post-CABG AF. Results: 103/312(33.01%) patients developed post-CABG AF. Univariate analysis showed that patients in AF group compared with those in non-AF group were more likely to have advanced age (≥ 70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement ( ≥40 mm), a history of AF, prolonged p-wave duration ( ≥ 120 ms) and increased number of grafts (≥3). Multivariate logistic regression analysis showed that advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm) and a history of AF were highly related to post-CABG AF. Conclusion: The incidence of AF in patients following CABG was 33.01% in this study. Advanced age, early postoperative withdrawal of β-blockers,hypertension, left atrial enlargement and a history of AF were independent risk factors of post-CABG AF.     

云南哈尼族CSF1PO,TPOX和THO1基因座多态性分析

应用３个ＳＴＲ基因座在同一反应体系中进行互不干扰的多重ＰＣＲ,采用高分辨力的聚丙烯酰胺弟胶电泳分离、银染法显影技术,对云南哈尼族的ＣＳＦ１ＰＯ,ＴＰＯＸ和ＴＨＯ１等３个基因座等基因的基因频率进行调查,ＣＳＦＩＰＯ基因座,观察到７个等基因,１７个基因型;ＴＰＯＸ基因座,以６个等基因,１３个基因型;ＴＨＯ１基因座,观察到６个等基因,１９个基因型,获得了满意的结果,显示了广阔的应用前景。